When part of the team falls ill after becoming targets of a sinister plot, it becomes an all-hands-on-deck situation to save them before it's too late. Meanwhile, Watson announces a new ambitious project that he has been working on.

When part of the team falls ill after becoming targets of a sinister plot, it becomes an all-hands-on-deck situation to save them before it's too late. Meanwhile, Watson announces a new ambitious project that he has been working on.

Watson confronts a traumatic event from his Army days that still weighs heavily on him when his Army veteran friend’s wife reaches out begging for help when her husband is seemingly having a psychotic break. Meanwhile, Shinwell is asked for one last favor by Moriarty.

Watson is thrown into a detective case when he is unsure whether the patient he is treating for one of the most rare ailments in the world, alien hand syndrome, is guilty of pushing his brother in front of a bus to his death.

Ingrid's lies come back to haunt her when her sister Gigi needs to be treated by the team after she develops side effects to the secret treatments Ingrid put her through. Also, Watson and Mary bond over a tragedy.

Watson runs into brilliant con artist and an old friend of Sherlock Holmes, Irene Adler, when her son Angus is admitted to UHOP for temporary paralysis. The fellows help Watson after he grows fond of Angus and pursue various leads to find a cure to his illness.

While Watson and the team help a woman whose memory resets every three minutes, Watson struggles with auditory hallucinations and questions whether someone is behind his current decline. Also, Moriarty plots his next move.

Watson and the fellows investigate the perplexing case of a family man with a bullet lodged in his head who insists he is a Scottish soldier and seems to be hiding something nefarious.

Morris Chestnut stars as Dr. John Watson, who resumes his medical career as the head of a clinic dedicated to treating rare disorders six months after the death of his friend and partner, Sherlock Holmes, at the hands of Moriarty. Watson’s old life isn’t done with him, though: Moriarty and Watson are set to write their own chapter of a story that has fascinated audiences for more than a century.